Flavonoids: Broad Spectrum Agents on Chronic Inflammation
10.4062/biomolther.2019.034
- Author:
Hyun LIM
1
;
Moon Young HEO
;
Hyun Pyo KIM
Author Information
1. College of Pharmacy, Kangwon National University, Chuncheon 24341, Republic of Korea. hpkim@kangwon.ac.kr
- Publication Type:Review
- Keywords:
Flavonoid;
Chronic inflammation;
Therapeutics;
Inflammaging;
Meta-inflammation
- MeSH:
Autophagy;
Flavonoids;
In Vitro Techniques;
Inflammasomes;
Inflammation;
Nitric Oxide Synthase;
Plants
- From:Biomolecules & Therapeutics
2019;27(3):241-253
- CountryRepublic of Korea
- Language:English
-
Abstract:
Flavonoids are major plant constituents with numerous biological/pharmacological actions both in vitro and in vivo. Of these actions, their anti-inflammatory action is prominent. They can regulate transcription of many proinflammatory genes such as cyclooxygenase-2/inducible nitric oxide synthase and many cytokines/chemokines. Recent studies have demonstrated that certain flavonoid derivatives can affect pathways of inflammasome activation and autophagy. Certain flavonoids can also accelerate the resolution phase of inflammation, leading to avoiding chronic inflammatory stimuli. All these pharmacological actions with newly emerging activities render flavonoids to be potential therapeutics for chronic inflammatory disorders including arthritic inflammation, meta-inflammation, and inflammaging. Recent findings of flavonoids are summarized and future perspectives are presented in this review.
