Differential Gene Expression Common to Acquired and Intrinsic Resistance to BRAF Inhibitor Revealed by RNA-Seq Analysis
10.4062/biomolther.2018.133
- Author:
Jun Ho AHN
1
;
Sung Hee HWANG
;
Hyun Soo CHO
;
Michael LEE
Author Information
1. System Toxicology Research Center, Korea Institute of Toxicology, Daejeon 34114, Republic of Korea.
- Publication Type:Original Article
- Keywords:
BRAF inhibitor;
Drug resistance;
Melanoma;
RNA-Seq analysis
- MeSH:
Antigen Presentation;
Biological Processes;
Cell Adhesion;
Cell Line;
Cell Movement;
Classification;
Collagen;
Drug Resistance;
Extracellular Matrix;
Gene Expression;
Gene Ontology;
Melanoma;
Osteoblasts;
Proto-Oncogene Proteins c-akt
- From:Biomolecules & Therapeutics
2019;27(3):302-310
- CountryRepublic of Korea
- Language:English
-
Abstract:
Melanoma cells have been shown to respond to BRAF inhibitors; however, intrinsic and acquired resistance limits their clinical application. In this study, we performed RNA-Seq analysis with BRAF inhibitor-sensitive (A375P) and
