Etiology of Adolescent Idiopathic Scoliosis: A Literature Review

Author: Sina Rashidi KIKANLOO ¹ ; Sandip Parshottam TARPADA ; Woojin CHO
Author Information

1. Department of Orthopedic Surgery, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA. wcho@montefiore.org
Publication Type:Review
Keywords: Adolescent; Scoliosis; Adolescent idiopathic scoliosis; Etiology; Cobb angle; Review
MeSH: Adolescent; Braces; Humans; Scoliosis; Spinal Curvatures
From:Asian Spine Journal 2019;13(3):519-526
CountryRepublic of Korea
Language:English
Abstract: Adolescent idiopathic scoliosis (AIS) is the peripubertal development of spinal curvature of a minimum of 10°. AIS is thought to be attributable to genetic factors, nutrition, early exposure to toxins, and hormonal dysregulation. Recent literature suggests these factors may compound to determine both disease onset and severity. Currently, treatment is limited to observation, bracing, and surgical intervention. Intervention is presently determined by severity and risk of curve progression. As they emerge, new therapies may target specific etiologies of AIS.