IgE-mediated allergy to proton pump inhibitors with both delayed and immediate onset
10.5415/apallergy.2019.9.e30
- Author:
Leyla BARAKAT
1
;
Maria João VASCONCELOS
;
Jean Luc BOURRAIN
;
Pascal DEMOLY
;
Anca Mirela CHIRIAC
Author Information
1. Centre Hospitalier Universitaire de Montpellier, Hôpital Arnaud-de-Villeneuve, Département de Pneumologie et Addictologie, unité Exploration des Allergies, 34295 Montpellier, France. a-chiriac@chu-montpellier.fr
- Publication Type:Case Report
- Keywords:
Anaphylaxis;
Hypersensivity, Delayed;
Drug hypersensitivity;
Proton pump inhibitors;
Skin tests
- MeSH:
Anaphylaxis;
Drug Hypersensitivity;
Female;
Gastrointestinal Diseases;
Humans;
Hypersensitivity;
Incidence;
Middle Aged;
Proton Pump Inhibitors;
Proton Pumps;
Protons;
Skin Tests
- From:
Asia Pacific Allergy
2019;9(4):e30-
- CountryRepublic of Korea
- Language:English
-
Abstract:
Proton pump inhibitors (PPIs) are widely used for the treatment of gastrointestinal diseases. Incidence of drug hypersensitivity reactions (DHRs) to PPIs has been rising, presumably because of their increased consumption. Most DHR are IgE-mediated, with half of the reactions being anaphylactic. We describe the case of a Caucasian 50-year-old female patient referred to our allergy department after 2 episodes of anaphylaxis. The allergy work-up distinguished PPI as a cause of delayed onset (14 hours) and immediate onset (45 minutes) IgE-mediated DHR.
