The risk of preschool asthma at 2–4 years is not associated with leukocyte telomere length at birth or at 1 year of age
10.5415/apallergy.2019.9.e33
- Author:
Dong In SUH
1
;
Mi Jin KANG
;
Yoon Mee PARK
;
Jun Kyu LEE
;
So Yeon LEE
;
Youn Ho SHEEN
;
Kyung Won KIM
;
Kangmo AHN
;
Soo Jong HONG
Author Information
1. Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Allergy;
Asthma;
Bronchial diseases;
Child, Preschool;
Oxidative stress, Telomere shortening
- MeSH:
Asthma;
Bronchial Diseases;
Child, Preschool;
Cohort Studies;
Follow-Up Studies;
Humans;
Hypersensitivity;
Leukocytes;
Oxidative Stress;
Parturition;
Telomere
- From:
Asia Pacific Allergy
2019;9(4):e33-
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Exposure to prenatal stress is associated with offspring allergic-disease development, and oxidative stress may mediate this relationship. OBJECTIVE: We aimed to evaluate whether leukocyte telomere length (LTL) shortening, a marker for exposure to oxidative stress, in early life is associated with increased risk of asthma development during the preschool period. METHODS: We assessed the follow-up clinical data of a subgroup from a birth cohort whose LTLs had been measured from cord-blood and 1-year peripheral-blood samples. We examined whether the LTLs would be associated with asthma development at the age of 2–4 years. RESULTS: The data of 84 subjects were analyzed. LTLs were measured from the cord-blood and 1-year peripheral blood of 75 and 79 subjects, respectively. Among them, 14 subjects (16.7%) developed bronchial asthma between 2–4 years old. Prenatally stressed subjects had marginally increased odds of developing asthma (p = 0.097). There was no significant difference in the odds of preschool-asthma development between the groups with shorter and longer cord-blood LTLs (odds ratio [OR], 0.651; 95% confidence interval [CI], 0.184–2.306) or in the odds between the groups with shorter and longer 1-year peripheral-blood LTLs (OR, 0.448; 95% CI, 0.135–1.483). Finally, subjects with both higher prenatal stress and shorter LTLs did not have significantly higher odds of preschool-asthma development (for cord-blood: OR, 1.242; 95% CI, 0.353–4.368; for 1-year peripheral-blood: OR, 1.451; 95% CI, 0.428–4.919). CONCLUSION: There was no significant association between early life LTLs and higher risk of bronchial-asthma development during the preschool years.
