The correlation between serum vascular endothelial growth factor (VEGF) and tumor VEGF receptor 3 in colorectal cancer
10.4174/astr.2019.97.1.15
- Author:
André GOULART
1
;
Carla FERREIRA
;
Ana RODRIGUES
;
Barbara COIMBRA
;
Nuno SOUSA
;
Pedro LEÃO
Author Information
1. General Surgery, Hospital de Braga, Braga, Portugal. andre.b.goulart@gmail.com
- Publication Type:Original Article
- Keywords:
Colorectal neoplasms;
Vascular endothelial growth factors;
Enzyme-linked immunosorbent assay;
Immunohistochemistry
- MeSH:
Biomarkers;
Body Mass Index;
Colorectal Neoplasms;
Colorectal Surgery;
Diagnosis;
Enzyme-Linked Immunosorbent Assay;
Humans;
Immunochemistry;
Immunohistochemistry;
Plasma;
Prospective Studies;
Receptors, Vascular Endothelial Growth Factor;
Vascular Endothelial Growth Factor A;
Vascular Endothelial Growth Factors
- From:Annals of Surgical Treatment and Research
2019;97(1):15-20
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Despite plasma biomarkers offering a number of advantages over tissue-based markers, the relationship between serum vascular endothelial growth factor (VEGF) and VEGF receptor (VEGF-R) tumor expression in colorectal cancer (CRC) is still unclear. This study was designed to establish the relationship between the concentration of serum VEGF and tumor VEGF-R expression in patients with CRC. METHODS: A prospective study of consecutive patients undergoing elective colorectal surgery during 1 year. Preoperative VEGF was determined by enzyme-linked immunosorbent assay and VEGF-R3 by immunochemistry. RESULTS: The initial sample included 134 patients with CRC diagnosis. Results showed significant association of serum values of VEGF with VEGF-R3 expression (P < 0.001), even in the presence of confounders (sex, age, body mass index, tumor location, and surgical approach). The estimated effect size was high (η² = 0.35). CONCLUSION: Serum VEGF has a significant correlation with tumoral VEGF-R3 expression in CRC.
