The roles of triglyceride/high-density lipoprotein cholesterol ratio and uric acid as predisposing factors for metabolic syndrome in healthy children
10.6065/apem.2019.24.3.172
- Author:
Maria Efthymia KATSA
1
;
Anastasios IOANNIDIS
;
Athanasios SACHLAS
;
Ioannis DIMOPOULOS
;
Stylianos CHATZIPANAGIOTOU
;
Andrea Paola ROJAS GIL
Author Information
1. Department of Nursing, Faculty of Health Sciences, University of Peloponnese, Tripolis, Greece. arojas@uop.gr
- Publication Type:Original Article
- Keywords:
Triglyceride/high-density lipoprotein cholesterol ratio;
Uric acid;
Metabolic syndrome;
Child
- MeSH:
Alanine Transaminase;
Body Mass Index;
Causality;
Child;
Cholesterol;
Humans;
Lipoproteins;
ROC Curve;
Transferases;
Uric Acid;
Waist Circumference
- From:Annals of Pediatric Endocrinology & Metabolism
2019;24(3):172-179
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To estimate the roles of triglyceride/high-density lipoprotein cholesterol (TG/HDL) ratio and uric acid in predisposition for metabolic syndrome (MetS) and its components in healthy children. METHODS: Anthropometric and biochemical analyses were performed on 110 children, aged 5 to 12 years, from the Greek county of Laconia. The children were studied as a whole population and in separate groups according to age and predisposition to MetS after taking into consideration International Diabetes Federation criteria, body mass index, and lipid profile. RESULTS: Seventeen percent of children exhibited predisposition to MetS, while 39.1% had TG/HDL ratio >1, and 3.64% had high level of uric acid. According to a receiver operating characteristic curve analysis, the relative probability for MetS predisposition sextupled when TG/HDL ratio was ≥1 (odds ratio [OR], 5.986; 95% confidence interval [CI], 1.968–18.205). Children in the total population and those aged < 9 years had a greater probability for increased low-density lipoprotein (LDL) cholesterol (OR, 3.614; 95% CI, 1.561–8.365) when TG/HDL ratio was ≥ 1. The TG/HDL ratio was positively correlated with body mass index (BMI) (P=0.035) in children without MetS, cholesterol in the total population (P=0.06) and children ≥9 years old (P=0.026), and with LDL in the total population and both age groups (P=0.001). The TG/HDL ratio was also positively correlated with alanine aminotransferase in the total population (P=0.033) and gamma-glutamyl transferase in most studied groups (P<0.001). Uric acid was positively correlated with waist circumference in the total population (P=0.043) and in those without MetS (P=0.027). It was also positively correlated with BMI, TG, cholesterol, and TG/HDL ratio and negatively correlated with HDL in most studied groups (P<0.005). CONCLUSION: The studied parameters correlated with MetS components and could be characterized as effective indexes for childhood MetS, regardless of age and predisposition to MetS.
