The effect of early extubation on postoperative delirium in patients with liver transplantation: a propensity score matching analysis
10.17085/apm.2019.14.3.322
- Author:
Yun Mi CHOI
1
;
Yoon Ji CHOI
;
Eun Ji CHOI
;
Hyun Su RI
;
Ju Yeon PARK
;
Kyung Hee KOH
;
Seung Zhoo YOON
;
Jae Ryung CHA
;
Kuen Su LEE
Author Information
1. Department of Anesthesia and Pain Medicine, Pusan National University Yangsan Hospital, Yangsan, Korea. yoonji07@gmail.com
- Publication Type:Original Article
- Keywords:
Airway extubation;
Delirium;
Liver transplantation;
Postoperative complication
- MeSH:
Airway Extubation;
Delirium;
Hospitalization;
Humans;
Hypnotics and Sedatives;
Incidence;
Intensive Care Units;
Intubation;
Liver Transplantation;
Liver;
Medical Records;
Operating Rooms;
Postoperative Complications;
Propensity Score;
Prospective Studies;
Respiration, Artificial;
Retrospective Studies;
Selection Bias
- From:Anesthesia and Pain Medicine
2019;14(3):322-330
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Maintenance of tracheal intubation is associated with use of sedatives, stress due to mechanical ventilation, or respiratory complications. The aim of this study is to compare the incidence of delirium between early and late extubation groups after liver transplantation (LT). METHODS: Medical records from 247 patients who received LT from January 2010 to July 2017 in a single university hospital were retrospectively reviewed. Patients were divided with 2 groups: Those who underwent early extubation after LT (E group, n = 52) and those who underwent extubation within few hours of intensive care unit (ICU) admission after surgery (C group, n = 195). The patients’ demographic data, perioperative managements and postoperative complications were collected. Early extubation was defined as performing extubation in the operating room after LT. A propensity score matching analysis was performed to reduce the effects of selection bias. RESULTS: Among them, 4/52 (7.69%) in E group and 30/195 (15.38%) in C group occurred postoperative delirium after LT, respectively (P = 0.180). After propensity score matching, there was no difference of the period of hospitalization in ICU (P = 0.961), time to discharge after surgery (P = 0.117) and incidence of delirium between groups (P = 1.000). CONCLUSIONS: Although this study is a retrospective study and limited by the small number of subjects, early extubation does not affect the incidence of delirium after LT. Therefore, further prospective studies on this were needed.
