Effects of benzydamine hydrochloride spray on postoperative sore throat associated with double-lumen endobronchial intubation: a double-blind, randomized controlled clinical trial
10.17085/apm.2019.14.2.180
- Author:
Sang Hi PARK
1
;
Seok Gon SON
;
Sang Tae KIM
Author Information
1. Department of Anesthesiology and Pain Medicine, Chungbuk National University Hospital, Cheongju, Korea. kimst@chungbuk.ac.kr
- Publication Type:Clinical Trial
- Keywords:
Benzydamine;
Intubation, intratracheal;
Pharyngitis;
Postoperative period
- MeSH:
Benzydamine;
Blood Pressure;
Deglutition Disorders;
Heart Rate;
Hoarseness;
Humans;
Incidence;
Intubation;
Intubation, Intratracheal;
Pharyngitis;
Postoperative Period;
Thoracic Surgery
- From:Anesthesia and Pain Medicine
2019;14(2):180-186
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Postoperative sore throat is a common complication of endotracheal intubation; the thicker the endotracheal tube, the higher the frequency of postoperative sore throat. So, we evaluated the effect of benzydamine hydrochloride spray on postoperative sore throat, associated with double-lumen endobronchial intubation. METHODS: Sixty patients undergoing thoracic surgery were scheduled and enrolled for intubation, with a double-lumen endobronchial tube. Of these patients, 30 were sprayed with benzydamine hydrochloride (group B), and 30 with normal saline (group N), 10 minutes before intubation was performed. Patients were randomly assigned to the two groups. Blood pressure and heart rate were recorded before, and after endotracheal intubation. Symptoms of sore throat, hoarseness, and dysphagia were examined one hour, as well as 24 hours, after surgery. RESULTS: Incidence of sore throat was 73.3% and 23.3% (P < 0.001) in groups N and B, respectively, at one hour after surgery. In addition, incidence of sore throat at 24 hours after the operation, was also statistically significant (66.6% and 20.0%, P = 0.001). Frequency of dysphagia at one hour, and 24 hours after surgery, was lower in group B. There were no significant differences in heart rate, blood pressure, and hoarseness at 24 hours after surgery between the two groups. CONCLUSIONS: In cases wherein a double-lumen endobronchial tube was used, an oropharyngeal spray of benzydamine hydrochloride before tracheal intubation, reduced incidence of postoperative sore throat.
