Age and Sex Distribution of Chinese Chronic Cough Patients and Their Relationship With Capsaicin Cough Sensitivity
10.4168/aair.2019.11.6.871
- Author:
Kefang LAI
1
;
Li LONG
;
Fang YI
;
Jiaman TANG
;
Zhe CHEN
;
Fagui CHEN
;
Jianmeng ZHOU
;
Wen PENG
;
Liting ZHANG
;
Hu LI
;
Wenzhi ZHAN
;
Ruchong CHEN
;
Wei LUO
;
Qiaoli CHEN
;
Kian Fan CHUNG
;
Nanshan ZHONG
Author Information
1. State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. klai@163.com
- Publication Type:Original Article
- Keywords:
Age distribution;
capsaicin;
cough;
sex distribution;
TRPV1 receptor
- MeSH:
Age Distribution;
Asian Continental Ancestry Group;
Asthma;
Capsaicin;
China;
Cough;
Female;
Healthy Volunteers;
Humans;
Male;
Reflex;
Sex Distribution
- From:Allergy, Asthma & Immunology Research
2019;11(6):871-884
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: An older female predominance has been reported among chronic cough patients in Western countries, which is considered to be associated with a higher cough sensitivity in females. However, the characteristics of Chinese chronic cough patients remain unclear. This study aimed to explore the age and sex distribution as well as their relationship with cough reflex sensitivity to capsaicin in Chinese chronic cough patients. METHODS: We analyzed the demographic features of 1,882 consecutive chronic cough patients who attended our cough clinic in Guangzhou, China. Cough sensitivity to capsaicin, which was defined as the lowest concentration of capsaicin causing 5 coughs or more (C5), was measured in 539 of the 1,882 patients and 68 healthy volunteers. RESULTS: The mean age of the patients was 43.0 ± 13.7 years and patients aged <50 years accounted for more than two-thirds of the study population. Around 87% of the patients were never-smokers. The proportion of females (51.5%) was almost equal to that of males (48.5%). The pattern of the age and sex distribution was consistently reflected within most common causes of chronic cough, while a female predominance was shown in patients with cough-variant asthma and patients aged ≥50 years. Female patients had higher cough sensitivity to capsaicin than male patients (log C5: 1.58 ± 0.84 vs. 2.04 ± 0.84 μmol/L, P = 0.001), and patients aged ≥50 years had higher cough sensitivity to capsaicin than patients aged <50 years. CONCLUSIONS: In China, patients with chronic cough have a roughly equal sex distribution and a middle-aged predominance, irrespective of a higher cough sensitivity to capsaicin in females and older patients. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT02591550
