MRI Assessment of Cerebral Small Vessel Disease in Patients with Spontaneous Intracerebral Hemorrhage
10.3349/ymj.2019.60.8.774
- Author:
Yong Sook PARK
1
;
Mi Sun CHUNG
;
Byung Sun CHOI
Author Information
1. Department of Neurosurgery, Chung-Ang University College of Medicine, Seoul, Korea. cuttage@cau.ac.kr
- Publication Type:Original Article
- Keywords:
Cerebral amyloid angiopathy;
cerebral small vessel disease;
hypertension;
intracranial hemorrhage
- MeSH:
Brain;
Cerebral Amyloid Angiopathy;
Cerebral Hemorrhage;
Cerebral Small Vessel Diseases;
Cognition Disorders;
Delivery of Health Care;
Humans;
Hypertension;
Intracranial Hemorrhages;
Magnetic Resonance Imaging;
Observational Study;
Retrospective Studies;
ROC Curve;
Stroke;
White Matter
- From:Yonsei Medical Journal
2019;60(8):774-781
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Cerebral small vessel disease (SVD) is known to be associated with ischemic stroke, intracerebral hemorrhage (ICH), and cognitive impairment. In this retrospective observational study, we explored SVD markers on MRI relevant to spontaneous ICH. MATERIALS AND METHODS: The ICH group consisted of 150 consecutive patients with a first primary parenchymal ICH, and the control group consisted of 271 age- and sex-matched individuals who underwent brain MRI in a health care center. We compared cerebral microbleeds (CMBs), white matter hyperintensities (WMHs), enlarged perivascular space (EPVS), and lacunae in the ICH and control groups. RESULTS: A total of 1278 CMB lesions were identified in 121 of the 150 patients in the ICH group (80.6%), while 77 CMB lesions were found in 32 of the 271 individuals in the control group (11.8%). WMH and EPVS were more severe and lacunae were more frequent in the ICH patients than in the control group. When receiver operating characteristic (ROC) curves were plotted, number of CMBs most significantly predicted ICH. All imaging markers were significantly associated with ICH in every age group. The location of CMBs coincided with the location of ICH, and ICH volume correlated with CMB count. CONCLUSION: All MRI markers for SVD were worse in ICH patients than in healthy controls, and these markers were prominent even in young ICH patients. Lacunae, WMH, EPVS, and CMB should be considered as factors related with spontaneous ICH.
