Long-Term Outcomes of Adult Lung Transplantation Recipients: A Single-Center Experience in South Korea
- Author:
Kyung Wook JO
1
;
Sang Bum HONG
;
Dong Kwan KIM
;
Sung Ho JUNG
;
Hyeong Ryul KIM
;
Se Hoon CHOI
;
Geun Dong LEE
;
Sang Oh LEE
;
Kyung Hyun DO
;
Eun Jin CHAE
;
In Cheol CHOI
;
Dae Kee CHOI
;
In Ok KIM
;
Seung Il PARK
;
Tae Sun SHIM
Author Information
- Publication Type:Original Article
- Keywords: Lung Transplantation; Survival; Chronic Lung Allograft Dysfunction; Chronic Kidney Disease
- MeSH: Adult; Allografts; Comorbidity; Diabetes Mellitus; Follow-Up Studies; Heart-Lung Transplantation; Humans; Idiopathic Pulmonary Fibrosis; Korea; Lung Transplantation; Lung; Mass Screening; Medical Records; Renal Insufficiency, Chronic; Retrospective Studies; Survival Rate; Tertiary Care Centers
- From:Tuberculosis and Respiratory Diseases 2019;82(4):348-356
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: Recently, the number of lung transplants in South Korea has increased. However, the long-term outcome data is limited. In this study, we aimed to investigate the long-term outcomes of adult lung transplantation recipients. METHODS: Among the patients that underwent lung transplantation at a tertiary referral center in South Korea between 2008 and 2017, adults patient who underwent deceased-donor lung transplantation with available follow-up data were enrolled. Their medical records were retrospectively reviewed. RESULTS: Through eligibility screening, we identified 60 adult patients that underwent lung (n=51) or heart-lung transplantation (n=9) during the observation period. Idiopathic pulmonary fibrosis (46.7%, 28/60) was the most frequent cause of lung transplantation. For all the 60 patients, the median follow-up duration for post-transplantation was 2.6 years (range, 0.01–7.6). During the post-transplantation follow-up period, 19 patients (31.7%) died at a median duration of 194 days. The survival rates were 75.5%, 67.6%, and 61.8% at 1 year, 3 years, and 5 years, respectively. Out of the 60 patients, 8 (13.3%) were diagnosed with chronic lung allograft dysfunction (CLAD), after a mean duration of 3.3±2.8 years post-transplantation. The CLAD development rate was 0%, 17.7%, and 25.8% at 1 year, 3 years, and 5 years, respectively. The most common newly developed post-transplantation comorbidity was the chronic kidney disease (CKD; 54.0%), followed by diabetes mellitus (25.9%). CONCLUSION: Among the adult lung transplantation recipients at a South Korea tertiary referral center, the long-term survival rates were favorable. The proportion of patients who developed CLAD was not substantial. CKD was the most common post-transplantation comorbidity.
