Understanding the pharmacokinetics of reversible metabolism
10.12793/tcp.2019.27.2.52
- Author:
Seungil CHO
1
,
2
,
3
;
Young Ran YOON
Author Information
1. Molecular Diagnostics and Imaging Center, Kyungpook National University
2. Department of Molecular Medicine, School of Medicine, Kyungpook National University
3. Department of Clinical Pharmacology, Clinical Trial Center, Kyungpook National University Hospital, Daegu 41944, Korea. chosi1@gmail.com, yry@knu.ac.kr
- Publication Type:Review
- Keywords:
Equilibrium approximation;
Matrix Method;
Pharmacokinetics;
Reversible Metabolism;
Steady-state approximation
- MeSH:
Metabolism;
Methods;
Pharmacokinetics
- From:Translational and Clinical Pharmacology
2019;27(2):52-58
- CountryRepublic of Korea
- Language:English
-
Abstract:
This tutorial introduces the mathematical skills required to obtain exact and approximate solutions for reversible reactions and provides graphical insights to help understand the pharmacokinetics of reversible metabolism. The matrix method provides an easy way to derive the exact solution for the amount of each species as a function of time. The plots of the exact solutions reveal some characteristic features of the pharmacokinetic profiles of the reversible metabolism. We also describe two approximation approaches, steady-state approximation, and equilibrium approximation, to simplify the solutions. The skills and knowledge acquired through this tutorial will provide a basis for understanding more complex reversible reaction systems.
