PKconverter: R package to convert the pharmacokinetic parameters
10.12793/tcp.2019.27.2.73
- Author:
Hyeseon CHO
1
;
Eun Kyung LEE
Author Information
1. Department of Statistics, Ewha Womans University, Seoul 03760, Korea. lee.eunk@ewha.ac.kr
- Publication Type:Original Article
- Keywords:
Pharmacokinetic model;
Pharmacokinetic parameter;
Population analysis;
R;
Shiny
- MeSH:
Drug Packaging;
Pharmaceutical Preparations;
Models, Biological;
Computer Simulation;
Software
- From:Translational and Clinical Pharmacology
2019;27(2):73-79
- CountryRepublic of Korea
- Language:English
-
Abstract:
Population pharmacokinetic analysis and modeling procedures typically require estimates of both population and individual pharmacokinetic parameters. However, only some of these parameters are contained in models and only parameters in the model can be estimated. In this paper, we introduce a new R package, PKconverter, to calculate pharmacokinetic parameters using the relationships among them. After fitting the model, other parameters can be calculated from the functional relationship among the parameters. PKconverter provides the functions to calculate whole parameters along with a Shiny application for converting the parameters. With this package, it is also possible to calculate the standard errors of the other parameters that are not in the model and estimate individual parameters simultaneously.
