Near-Infrared Contrast Agents for Bone-Targeted Imaging
10.1007/s13770-019-00208-9
- Author:
Jin Seok JUNG
1
;
Danbi JO
;
Gayoung JO
;
Hoon HYUN
Author Information
1. Department of Biomedical Sciences, Chonnam National University Medical School, 160 Baekseo-ro, Dong-gu, Gwangju 61469, South Korea. hhyun@jnu.ac.kr
- Publication Type:Review
- Keywords:
Near-infrared fluorescence imaging;
Contrast agents;
Bone-targeted imaging;
Image-guided surgery
- MeSH:
Bone and Bones;
Bone Development;
Contrast Media;
Diagnosis;
Diphosphonates;
Fluorescence;
Ligands;
Neoplasm Metastasis;
Optical Imaging;
Surgery, Computer-Assisted
- From:
Tissue Engineering and Regenerative Medicine
2019;16(5):443-450
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: For the bone-specific imaging, a structure-inherent targeting of bone tissue recently has been reported a new strategy based on incorporation of targeting moieties into the chemical structure of near-infrared (NIR) contrast agents, while conventional methods require covalent conjugation of bone-targeting ligands to NIR contrast agents. This will be a new approach for bone-targeted imaging by using the bifunctional NIR contrast agents. METHODS: The goal of this review is to provide an overview of the recent advances in optical imaging of bone tissue, highlighting the structure-inherent targeting by developing NIR contrast agents without the need for a bone-targeting ligand such as bisphosphonates. RESULTS: A series of iminodiacetated and phosphonated NIR contrast agents for the structure-inherent targeting of bone tissue showed excellent bone-targeting ability in vivo without non-specific binding. Additionally, the phosphonated NIR contrast agents could be useful in the diagnosis of bone metastasis. CONCLUSION: By developing bone-targeted NIR contrast agents, optical imaging of bone tissue makes it very attractive for preclinical studies of bone growth or real-time fluorescence guided surgery resulting in high potential to shift the clinical paradigms.
