Multimodal Composite Iron Oxide Nanoparticles for Biomedical Applications
10.1007/s13770-019-00218-7
- Author:
Shameer PILLARISETTI
1
;
Saji UTHAMAN
;
Kang Moo HUH
;
Yang Seok KOH
;
Sangjoon LEE
;
In Kyu PARK
Author Information
1. Department of Biomedical Science, BK21 PLUS Center for Creative Biomedical Scientists, Chonnam National University Medical School, 42 Jebong-ro, Dong-gu, Gwangju 61469, Republic of Korea. pik96@jnu.ac.kr
- Publication Type:Review
- Keywords:
Iron oxide nanoparticles;
Magnetic resonance imaging;
Ultrasound imaging;
Photoacoustic imaging;
Optical imaging
- MeSH:
Colloids;
Iron;
Magnetic Resonance Imaging;
Multimodal Imaging;
Nanoparticles;
Optical Imaging;
Polymers;
Theranostic Nanomedicine;
Ultrasonography
- From:
Tissue Engineering and Regenerative Medicine
2019;16(5):451-465
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Iron oxide nanoparticles (IONPs) are excellent candidates for biomedical imaging because of unique characteristics like enhanced colloidal stability and excellent in vivo biocompatibility. Over the last decade, material scientists have developed IONPs with better imaging and enhanced optical absorbance properties by tuning their sizes, shape, phases, and surface characterizations. Since IONPs could be detected with magnetic resonance imaging, various attempts have been made to combine other imaging modalities, thereby creating a high-resolution imaging platform. Composite IONPs (CIONPs) comprising IONP cores with polymeric or inorganic coatings have recently been documented as a promising modality for therapeutic applications. METHODS: In this review, we provide an overview of the recent advances in CIONPs for multimodal imaging and focus on the therapeutic applications of CIONPs. RESULTS: CIONPs with phototherapeutics, IONP-based nanoparticles are used for theranostic application via imaging guided photothermal therapy. CONCLUSION: CIONP-based nanoparticles are known for theranostic application, longstanding effects of composite NPs in in vivo systems should also be studied. Once such issues are fixed, multifunctional CIONP-based applications can be extended for theranostics of diverse medical diseases in the future.
