Biomaterials for the Treatment of Tendon Injury
10.1007/s13770-019-00217-8
- Author:
Sung Eun KIM
1
;
Jae Gyoon KIM
;
Kyeongsoon PARK
Author Information
1. Department of Orthopedic Surgery and Rare Diseases Institute, Korea University Guro Hospital, Korea University College of Medicine, 148 Gurodong-ro, Guro-gu, Seoul 08308, Republic of Korea.
- Publication Type:Review
- Keywords:
Tendon healing;
Delivery;
Biomaterials;
Regenerative factor;
Blood vessel
- MeSH:
Biocompatible Materials;
Blood Vessels;
Regenerative Medicine;
Sports;
Tears;
Tendon Injuries;
Tendons;
Weight-Bearing
- From:
Tissue Engineering and Regenerative Medicine
2019;16(5):467-477
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Most tendon injuries are occurring from a gradual wearing and tearing of the tendon tissues from overuse. Such injuries are usually seen in sports, exercising, or daily activities that involve a high mechanical load and weight bearing. However, owing to the lack of both cellularity and blood vessels in tendons, the process of tendon repair is slow and inefficient. Although various conservative (non-surgical) and surgical management options are conducted by the clinicians, a gold standard of these approaches does not exist. In this regard, the treatment of tendon injuries is challenging. METHODS: Here, we describe the recent advances of biomaterial-based approaches for the treatment of injured tendons. RESULTS: Regenerative medicine is an emerging multidisciplinary research that specializes in the repair of damaged tendon tissues through the delivery of regenerative factors by biomaterials. CONCLUSION: Although current biomaterial-based treatment strategies have shown their potential for tendon healing, future research and clinical applications should focused on finding the optimum combinations of regenerative factors with ideal biomaterials for the repair of tendons.
