Dexamethasone Downregulates Expressions of 14-3-3β and γ-Isoforms in Mice with Eosinophilic Meningitis Caused by Angiostrongylus cantonensis Infection
10.3347/kjp.2019.57.3.249
- Author:
Hung Chin TSAI
1
;
Yu Hsin CHEN
;
Chuan Min YEN
;
Li Yu CHUNG
;
Shue Ren WANN
;
Susan Shin Jung LEE
;
Yao Shen CHEN
Author Information
1. Section of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan and National Yang-Ming University, Taipei, Taiwan. hctsai1011@yahoo.com.tw
- Publication Type:Original Article
- Keywords:
Angiostrongylus cantonensis;
dexamethasone;
eosinophile;
meningitis;
14-3-3 isoform
- MeSH:
Angiostrongylus cantonensis;
Angiostrongylus;
Animals;
Brain;
Dexamethasone;
Eosinophils;
Humans;
Meninges;
Meningitis;
Mice;
Protein Isoforms;
Steroids
- From:The Korean Journal of Parasitology
2019;57(3):249-256
- CountryRepublic of Korea
- Language:English
-
Abstract:
Steroids are commonly used in patients with eosinophilic meningitis caused by A. cantonensis infections. The mechanism steroids act on eosinophilic meningitis remains unclear. In this mouse experiments, expressions of 14-3-3 isoform β and γ proteins significantly increased in the CSF 2–3 weeks after the infection, but not increasedin the dexamethasone-treated group. Expression of 14-3-3 β, γ, ɛ, and θ isoforms increased in brain meninges over the 3-week period after infection and decreased due to dexamethasone treatment. In conclusion, administration of dexamethasone in mice with eosinophilic meningitis decreased expressions of 14-3-3 isoform proteins in the CSF and in brain meninges.
