Characterization of Plasmodium berghei Homologues of T-cell Immunomodulatory Protein as a New Potential Candidate for Protecting against Experimental Cerebral Malaria
10.3347/kjp.2019.57.2.101
- Author:
Ai CUI
1
;
Yucen LI
;
Xia ZHOU
;
Lin WANG
;
Enjie LUO
Author Information
1. Department of Pathogen Biology, College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning 110122, P.R. China. enjie359@163.com
- Publication Type:Original Article
- Keywords:
Plasmodium berghei;
T-cell immunomodulatory protein;
inflammatory cytokine;
experimental;
cerebral malaria;
immunopathology
- MeSH:
Animals;
Brain;
Cytokines;
Down-Regulation;
Estrogens, Conjugated (USP);
Graft vs Host Disease;
Injections, Intravenous;
Malaria, Cerebral;
Membrane Proteins;
Mice;
Models, Animal;
Pathology;
Plasmodium berghei;
Plasmodium;
Staphylococcal Protein A;
T-Lymphocytes
- From:The Korean Journal of Parasitology
2019;57(2):101-115
- CountryRepublic of Korea
- Language:English
-
Abstract:
The pathogenesis of cerebral malaria is biologically complex and involves multi-factorial mechanisms such as microvascular congestion, immunopathology by the pro-inflammatory cytokine and endothelial dysfunction. Recent data have suggested that a pleiotropic T-cell immunomodulatory protein (TIP) could effectively mediate inflammatory cytokines of mammalian immune response against acute graft-versus-host disease in animal models. In this study, we identified a conserved homologue of TIP in Plasmodium berghei (PbTIP) as a membrane protein in Plasmodium asexual stage. Compared with PBS control group, the pathology of experimental cerebral malaria (ECM) in rPbTIP intravenous injection (i.v.) group was alleviated by the downregulation of pro-inflammatory responses, and rPbTIP i.v. group elicited an expansion of regulatory T-cell response. Therefore, rPbTIP i.v. group displayed less severe brain pathology and feverish mice in rPbTIP i.v. group died from ECM. This study suggested that PbTIP may be a novel promising target to alleviate the severity of ECM.
