- Author:
Ji Sook PARK
1
;
Hye Ok LEE
;
Young Seol KIM
;
Jung Eun YIM
Author Information
- Publication Type:Original Article
- Keywords: Caloric restriction; Intermuscular adipose tissue (IMAT); Obesity
- MeSH: Adipose Tissue; Caloric Restriction; Fasting; Female; Glucose; Humans; Insulin; Intra-Abdominal Fat; Leptin; Obesity; Risk Factors; Subcutaneous Fat; Thigh; Tomography, X-Ray Computed; Triglycerides; Waist Circumference
- From:Korean Journal of Obesity 2015;24(1):44-50
- CountryRepublic of Korea
- Language:Korean
- Abstract: BACKGROUND: This study investigated the effects of caloric restriction on thigh intermuscular adipose tissue (IMAT) and the associations of IMAT and metabolic risk factors. METHODS: Thirty-three obese Korean women (BMI 27.2+/-2.5 kg/m2; 32.3+/-8.7 years) were tested before and after 12 weeks of 354.7 kcal/day dietary caloric restriction: waist circumference (WC); %fat according to bioimpedence; subcutaneous adipose tissue (SAT); visceral adipose tissue (VAT); IMAT using single-slice CT scans at the levels of L4/L5 and mid-thigh (midpoint between the anterior iliac crest and patella); fasting levels of leptin, glucose, insulin, triglycerides, total-C, LDL-C, HDL-C, and HOMA-IR. Paired t-test and Spearman correlation analysis were performed. RESULTS: WC, %fat, leptin, glucose, total-C, abdominal SAT and VAT, and mid-thigh IMAT decreased (P<0.05), and %change in mid-thigh IMAT correlated with %change in HOMA-IR (P<0.05). CONCLUSION: Caloric restriction decreased the mid-thigh IMAT in obese Korean women, which may be correlated with reduction of metabolic risk.