Angiotensin II type 1 receptor antibodies in kidney transplantation
10.4285/jkstn.2019.33.1.6
- Author:
Hyeyoung LEE
1
;
Eun Jee OH
Author Information
1. Department of Laboratory Medicine, International St. Mary's Hospital, College of Medicine, Catholic Kwandong University, Incheon, Korea.
- Publication Type:Review
- Keywords:
Transplantation;
Receptor;
Angiotensin, type 1;
Kidney
- MeSH:
Activating Transcription Factors;
Allografts;
Angiotensin II;
Angiotensins;
Antibodies;
Enzyme-Linked Immunosorbent Assay;
Graft Survival;
Humans;
Kidney Transplantation;
Kidney;
Leukocytes;
Muscle, Smooth, Vascular;
Receptor, Angiotensin, Type 1;
Tissue Donors;
Transplantation
- From:The Journal of the Korean Society for Transplantation
2019;33(1):6-12
- CountryRepublic of Korea
- Language:English
-
Abstract:
Angiotensin II type 1 receptor (AT1R) antibodies directly injure endothelial and vascular smooth muscle cells by activating transcription factors associated with proinflammatory responses. Previous studies have shown that AT1R antibodies are associated with allograft rejection and decreased graft survival in kidney transplantation. Development of enzyme-linked immunosorbent assay has facilitated semiquantitative detection of AT1R antibodies. Assessing AT1R antibodies along with donor specific human leukocyte antigen antibodies may have potential to identify patients with possible risk for allograft injury and improve overall outcomes. In this review, we summarize recent clinical studies about AT1R antibodies in kidney transplantation and provide perspectives for future research area.
