Metronidazole-induced Reversible Cerebellopathy
- Author:
Ha Cheol CHOI
1
;
Sun Young OH
;
Byoung Soo SHIN
;
Man Wook SEO
;
Young Hyun KIM
Author Information
1. Department of Neurology, Chonbuk National University College of Medicine, Jeonju, Korea. ohsun@chonbuk.ac.kr
- Publication Type:Case Report
- Keywords:
Metronidazole;
Reversible encephalopathy
- MeSH:
Ataxia;
Brain;
Cerebellar Ataxia;
Cerebellar Diseases;
Helicobacter pylori;
Humans;
Metronidazole;
Peripheral Nervous System Diseases;
Protozoan Infections;
Seizures
- From:Journal of the Korean Balance Society
2009;8(2):132-136
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Metronidazole is a nitroimidazole antibiotic used for anaerobic infections, protozoan infections, and Helicobacter pylori infections. It may produce rare but well known neurological adverse effects including peripheral neuropathy, encephalopathy, cerebellar dysfunction, and seizures. We describe three patients with metronidazole-induced reversible cerebellar dysfunctions characterized by abnormal oculomotor findings, dysmetria, and ataxia. The diagnosis of metronidazole toxicity was made clinically and supported by the brain MRI findings. The neurological signs and abnormal signal intensity on MRI resolved after discontinuation of metronidazole.
