Initial Seizure Threshold in Brief-Pulse Bilateral Electroconvulsive Therapy in Patients with Schizophrenia or Schizoaffective Disorder
- Author:
Seong Hoon JEONG
1
;
Tak YOUN
;
Younsuk LEE
;
Jin Hyeok JANG
;
Young Wook JEONG
;
Yong Sik KIM
;
In Won CHUNG
Author Information
- Publication Type:Original Article
- Keywords: Schizophrenia; Schizoaffective disorder; Initial seizure threshold; Electroconvulsive therapy; Brief-pulse width; Bilateral electrode placement
- MeSH: Anesthesia; Diagnostic and Statistical Manual of Mental Disorders; Electroconvulsive Therapy; Electronic Health Records; Humans; Male; Psychotic Disorders; Schizophrenia; Seizures; Sodium; Thiopental
- From:Psychiatry Investigation 2019;16(9):704-712
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVE: The present study aimed to report the initial seizure threshold (IST) of a brief-pulse bilateral electroconvulsive therapy (BP-BL ECT) in Korean patients with schizophrenia/schizoaffective disorder and to identify IST predictors. METHODS: Among 67 patients who received ECT and diagnosed with schizophrenia/schizoaffective disorder based on the criteria of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision, we included 56 patients who received 1-millisecond BP-BL ECT after anesthesia with sodium thiopental between March 2012 and June 2018. Demographic and clinical information was gathered from electronic medical records, and a multiple regression analysis was conducted to identify predictors of the IST. RESULTS: The mean age of the patients was 36.9±12.0 years and 30 (53.6%) patients were male. The mean and median IST were 105.9±54.5 and 96 millicoulombs (mC), respectively. The IST was predicted by age, gender, and dose (mg/kg) of sodium thiopental. Other physical and clinical variables were not associated with the IST. CONCLUSION: The present study demonstrated that the IST of 1-ms BP-BL ECT following sodium thiopental anesthesia in Korean patients was comparable to those reported in previous literature. The IST was associated with age, gender, and dose of sodium thiopental.
