An Exploration of the Oryza sativa L. Cyanidin-3-glucoside on the Cognitive Function in Older Adults with Subjective Memory Impairment
- Author:
Soo Hyun JOO
1
;
Changtae HAHN
;
Hyun Kook LIM
;
Kee Dong YOON
;
Shin Hee YOON
;
Chang Uk LEE
Author Information
- Publication Type:Randomized Controlled Trial
- Keywords: Oryza sativa L; Cyanidin-3-glucoside; Cognitive function; Safety
- MeSH: Adult; Anthocyanins; Capsules; Cognition; Dementia; Hematologic Tests; Humans; Memory; Oryza
- From:Psychiatry Investigation 2019;16(10):759-765
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVE: Cyanidin-3-glucoside (C3G), is a component of anthocyanin, have been considered to positively influence cognition and be beneficial for the prevention and treatment of dementia. We aimed to assess the safety and efficacy of cyanidin-3-glucoside-rich Oryza sativa L. (black rice) extract on cognitive function. METHODS: A 12-weeks double-blind randomized, placebo controlled trial assessed safety and cognitive outcomes in participants with subjective memory impairment (n=48) following consumption of 6 black rice extract capsules or a placebo. Cognitive function was assessed using the ADAS-cog and the CERAD-K. Subjective memory impairment also assessed. Safety was assessed by hematologic blood test, urine analysis, and participant reports of adverse events. RESULTS: There was significant improvement on subjective memory in intervention group. There was no statistically significant difference in objective cognitive outcomes following 12 weeks of consuming black rice extract. ADAS-cog scores, however, trended toward improvement in the intervention group compared to the placebo group. There was no adverse event. CONCLUSION: Although significant improvement in objective cognitive function was not proved, we found that C3G-rich Oryza sativa L. extract improves subjective memory in this study. Therefore the results may be informative of the possible effectiveness of the C3G-rich Oryza sativa L. on cognitive function.
