Comparison of Proportions of Lymphocyte Subsets According to Serum 25(OH) Vitamin D Levels in Postmenopausal Women
- Author:
Hyo Jin LEE
1
;
Seon Yong BHANG
;
Jee Hyun KANG
;
Byung Yeon YU
;
Sung Ki LEE
Author Information
1. Department of Family Medicine, College of Medicine, Konyang University, Daejeon, Korea. jeehyunkang@yahoo.co.kr
- Publication Type:Original Article
- Keywords:
25(OH) Vitamin D;
T lymphocyte;
Postmenopausal women
- MeSH:
Female;
Humans;
Lymphocyte Subsets;
Lymphocytes;
Vitamin D;
Vitamins
- From:Journal of Korean Society of Osteoporosis
2014;12(3):103-110
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUNDS: Many reports have proposed a significant role for vitamin D in immune mediated disease. This study analyzed the lymphocyte subsets according to serum 25(OH) vitamin D levels in postmenopausal women to determine the potential effect of vitamin D on immune-mediated disease. METHODS: We enrolled 31 postmenopausal women who underwent health checkup in a university hospital. Peripheral blood samples were taken for the investigation of the levels of T, B, and natural killer (NK) cells and the, proportion of CD3+, CD4+ ,CD8+, Th1, Th2, Th17 and Treg subsets of T lymphocyte in the morning after overnight fast. We also measured serum 25(OH) Vitamin D and evaluated the relationship between vitamin D levels and lymphocyte subpopulations. RESULTS: The subjects were divided into three groups according to serum vitamin D levels. There was no significant correlation between the level of vitamin D and the percentages of three lymphocyte subtypes. The proportion of CD4+ T cell (P for trend 0.024) and the CD4+/CD8+ T cell ratio(P for trend 0.000) was declined across increasing tertiles of vitamin D levels. The proportion of CD8+T cell was increased with increasing of tertiles of vitamin D levels (P for trend 0.004). And the results showed that the CD4+/CD8+ T cell ratio differed significantly between the groups with lowest and the middle vitamin D levels and between the groups with lowest and the highest. CONCLUSIONS: Serum vitamin D levels in postmenopausal women are associated with changes in the peripheral T cell compartment. These results provide insight into the immunomodulatory properties of vitamin D andthe possible beneficial associations between vitamin Dand immune-mediated disease.
