Seven Year-follow-up of a Brown Tumor in the Maxilla Associated with Secondary Hyperparathyroidism in End-stage Renal Failure
- Author:
Wonjin KIM
1
;
Daham KIM
;
Su Jin LEE
;
Sung Kil LIM
;
Yumie RHEE
Author Information
1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. YUMIE@yuhs.ac
- Publication Type:Case Report
- Keywords:
Brown tumor;
Secondary hyperparathyroidism;
Chronic kidney disease
- MeSH:
Bone Density;
Calcium;
Clavicle;
Creatinine;
Female;
Femur Neck;
Fibroblasts;
Follow-Up Studies;
Forearm;
Humans;
Hypercalcemia;
Hyperparathyroidism;
Hyperparathyroidism, Secondary;
Hyperphosphatemia;
Hypocalcemia;
Kidney Failure, Chronic;
Kidney Transplantation;
Mandible;
Maxilla;
Osteoclasts;
Parathyroid Glands;
Parathyroidectomy;
Pelvic Bones;
Reference Values;
Renal Dialysis;
Renal Insufficiency, Chronic;
Ribs;
Spine;
Tooth;
Transplants
- From:Journal of Korean Society of Osteoporosis
2012;10(2):82-89
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Hyperparathyroidism is a frequent complication of chronic kidney disease (CKD) as a result of prolonged hyperphosphatemia and hypocalcemia. Brown tumor is a rare bony complication of hyperparathyroidism as a result of increased osteoclastic activity and fibroblastic proliferation. Frequent sites of brown tumor are known as ribs, clavicles, mandible, and pelvic bone, but maxilla is very rare site. Twenty seven-year-old woman with stage V CKD on hemodialysis presented with maxillary mass which had gradually increased in size for 3 years. It was painless, but tooth derangement occurred. Initial laboratory findings revealed hypercalcemia (11.0 mg/dL), hyperphosphatemia (6.9 mg/dL), high creatinine (7.5 mg/dL), and high serum PTH (1729.9 pg/mL). The bone mineral density was significantly low (lumbar spine Z-score:
