The Study of Bisphosphonate and Postmenopausal Hormone Treatment in Low Bone Mineral Density
- Author:
Soo Ah KIM
1
;
Ari KIM
;
Yong il JI
;
Heung Yeol KIM
;
Jong Soon CHOI
;
Won Jun CHOI
;
Min Hyung JUNG
;
Ji Young LEE
;
Hyuk JUNG
Author Information
1. Department of Obstetrics and Gynecology, Medical School, Chosun University, Gwangju, Korea.
- Publication Type:Original Article
- Keywords:
Bisphosphonate;
Bone mineral density;
Hormone therapy;
Menopause
- MeSH:
Absorptiometry, Photon;
Alendronate;
Bone Density;
Female;
Humans;
Menopause;
Spine
- From:Journal of Korean Society of Osteoporosis
2011;9(1):132-138
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: To evaluate the effect of postmenopausal hormone therapy alone or in combination with bisphosphonate on bone mineral density (BMD) in postmenopausal women. METHODS: One hundred three women diagnosed with low BMD in postmenopausal women were included in this study. All patients were classified into two groups; oarl hormone therpy alone (Group I) or with alendronate (Group II), given for 12 months. Dual energy X-ray absorptiometry was used to measure BMD before and after 12 months of treatment. RESULTS: In all groups, significant increase in bone density measurements were seen at 12 months of treatment. The BMD of lumbar spine more increased significantly in Group II than Group I. CONCLUSIONS: Postmenopausal hormone therapy is effective in osteopenic and osteoporotic women. However, the combined treatment with hormone therapy and bisphophonate is more effective in postmenopausal women with low BMD.