Early reduced bone formation following burn injury in rats is not inversely related to marrow adiposity
10.1016/j.afos.2019.08.001
- Author:
Amina EL AYADI
1
;
Ron C HELDERMAN
;
Celeste C FINNERTY
;
David N HERNDON
;
Clifford J ROSEN
;
Gordon L KLEIN
Author Information
1. Departments of Surgery and Orthopaedic Surgery and Rehabilitation, University of Texas Medical Branch and Shriners Burns Hospital, Galveston TX and Maine Medical Research Institute, Scarborough, ME, USA. gordonklein@ymail.com
- Publication Type:Original Article
- Keywords:
Burns;
Osteocalcin;
Marrow adipocytes;
Child;
Bone formation
- MeSH:
Adipocytes;
Adiposity;
Animals;
Bone Marrow;
Burns;
Child;
Glucose;
Humans;
Metabolism;
Models, Animal;
Osteocalcin;
Osteogenesis;
Oxidative Stress;
Rats
- From:Osteoporosis and Sarcopenia
2019;5(3):82-84
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVES: The objective of the study was to determine whether postburn reduction of bone formation occurred earlier than 2–3 weeks after burn injury and whether that reduction was inversely related to marrow adiposity. METHODS: Using a rat model of burn injury with sacrifice at 3 days postburn, we measured serum osteocalcin, a biomarker of bone formation, as well as a regulator of glucose metabolism, and counted tibial marrow adipocytes. RESULTS: Serum osteocalcin was reduced as early as 3 days postburn, coinciding with a trend toward decline in marrow adipocyte number rather than demonstrating an inverse relationship with adipocyte count. CONCLUSIONS: Factors that may be responsible for the dissociation include lack of circulating sclerostin, previously reported, increased energy demands following burn injury, increased sympathetic tone and perhaps oxidative stress. The relationship between bone formation and marrow adiposity is complex and subject to a variety of influences.
