Oxidative stress markers and lipid profiles of patients with polycystic ovary syndrome in a Nigerian tertiary hospital
10.5468/ogs.2019.62.5.335
- Author:
Chukwunonso Isaiah ENECHUKWU
1
;
Anaelechi Jude ONUEGBU
;
Madu Japheth OLISEKODIAKA
;
George Uchenna ELEJE
;
Joseph Ifeanyichukwu IKECHEBELU
;
Joseph Odirichukwu UGBOAJA
;
Ubuo Kalu AMAH
;
John Ekenedirichukwu OKWARA
;
Anthony Osita IGWEGBE
Author Information
1. Department of Obstetrics & Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Nigeria, Nigeria. nkystarme@gmail.com
- Publication Type:Original Article
- Keywords:
Polycystic ovary syndrome;
Oxidative stress;
Dyslipidaemia;
Obesity;
Cardiometabolic risks
- MeSH:
Body Mass Index;
Case-Control Studies;
Cholesterol;
Female;
Glutathione Peroxidase;
Hospitals, Teaching;
Humans;
Lipoproteins;
Malondialdehyde;
Nigeria;
Obesity;
Oxidative Stress;
Polycystic Ovary Syndrome;
Superoxide Dismutase;
Tertiary Care Centers;
Triglycerides;
Waist Circumference;
Waist-Hip Ratio
- From:Obstetrics & Gynecology Science
2019;62(5):335-343
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: To determine the activities of oxidative stress markers and lipid profiles of patients with polycystic ovary syndrome (PCOS) in Nnamdi Azikiwe University Teaching Hospital Nnewi, Nigeria. METHODS: This was a nested case-control study consisting of 50 PCOS patients and 50 healthy women of the same age range without any evidence of PCOS. The study measured the levels of malondialdehyde (MDA), activity of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), total antioxidant capacity (TAC); concentrations of total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C), as well as high-density lipoprotein cholesterol (HDL-C) using standard spectrophotometric methods. Anthropometric indices were also assessed. P-values of <0.05 were taken to be statistically significant. RESULTS: There were significantly higher levels of MDA (P=0.002), lower activity of SOD (P<0.001), and lower TAC (P=0.001) in PCOS patients when compared with the controls. There were higher concentrations of TC (P=0.017) and LDL-C P=0.012) in PCOS patients than in controls. Significant differences were not observed between the 2 groups in terms of the activity of GSH-Px, as well as the concentrations of HDL-C and TG. The body mass index, waist circumference, and waist-hip ratio were all significantly higher in PCOS patients. CONCLUSION: This study revealed higher levels of MDA, as well as lower activity of SOD and TAC, among PCOS patients. Furthermore, there were higher levels of TC and LDL-C among the PCOS patients. Hence, monitoring these parameters may improve the clinical management of PCOS.
