Pathogenetic factors involved in recurrent pregnancy loss from multiple aspects
10.5468/ogs.2019.62.4.212
- Author:
Chang Zhu PEI
1
;
Young Ju KIM
;
Kwang Hyun BAEK
Author Information
1. Department of Biomedical Science, CHA University, CHA General Hospital, Seongnam, Korea, Seoul, Korea. baek@cha.ac.kr
- Publication Type:Review
- Keywords:
Proteomics;
Recurrent miscarriage;
Vitamin D
- MeSH:
Abortion, Habitual;
Abortion, Spontaneous;
Colony-Stimulating Factors;
Embryo Implantation;
Embryonic Development;
Female;
Fertilization;
Fetal Development;
Gene Expression;
Glucose;
Humans;
Inflammation;
Killer Cells, Natural;
Metabolism;
MicroRNAs;
Obstetrics;
Pregnancy;
Proteomics;
T-Lymphocytes;
Tumor Necrosis Factor-alpha;
Vitamin D
- From:Obstetrics & Gynecology Science
2019;62(4):212-223
- CountryRepublic of Korea
- Language:English
-
Abstract:
Recurrent pregnancy loss (RPL) is a common complication in obstetrics, affecting about 5% of women of childbearing age. An increase in the number of abortions results in escalation in the risk of miscarriage. Although concentrated research has identified numerous causes for RPL, about 50% of them remain unexplained. Pregnancy is a complex process, comprising fertilization, implantation, organ and tissue differentiation, and fetal growth, which is effectively controlled by a number of both maternal and fetal factors. An example is the immune response, in which T cells and natural killer cells participate, and inflammation mediated by tumor necrosis factor or colony-stimulating factor, which hinders embryo implantation. Furthermore, vitamin D affects glucose metabolism and inhibits embryonic development, whereas microRNA has a negative effect on the gene expression of embryo implantation and development. This review examines the causes of RPL from multiple perspectives, and focuses on the numerous factors that may result in RPL.
