How much have the perinatal outcomes of triplet pregnancies improved over the last two decades?
10.5468/ogs.2019.62.4.224
- Author:
Kyu Sang KYEONG
1
;
Jae Yoon SHIM
;
Soo young OH
;
Hye Sung WON
;
Pil Ryang LEE
;
Ahm KIM
;
Sung Cheol YUN
;
Pureun Narae KANG
;
Suk Joo CHOI
;
Cheong Rae ROH
Author Information
1. Department of Obstetrics and Gynecology, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Korea.
- Publication Type:Original Article
- Keywords:
Triplets;
Pregnancy;
Preterm birth;
Pregnancy outcome
- MeSH:
Anemia;
Female;
Gestational Age;
Humans;
Incidence;
Infant, Newborn;
Logistic Models;
Medical Records;
Pre-Eclampsia;
Pregnancy;
Pregnancy Outcome;
Pregnancy, Triplet;
Premature Birth;
Retrospective Studies;
Triplets
- From:Obstetrics & Gynecology Science
2019;62(4):224-232
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: This study was conducted to demonstrate the temporal trends in perinatal outcomes of triplet pregnancies over the last two decades. METHODS: The medical records of patients with triplet pregnancies at two Korean tertiary-care hospitals from 1992 to 2012 were retrospectively reviewed in regard to maternal and neonatal outcomes. The study was divided into two periods for analysis: period I (1992–2001) and period II (2003–2012). RESULTS: Over a 21-year period, 65 women with triplet pregnancies and 185 neonates were analyzed. Period II, when compared with period I, was associated with improved maternal outcomes, characterized by a decreased incidence of preeclampsia (31.8% vs. 2.3%, P=0.002) and anemia (68.2% vs. 30.2%, P=0.003) during pregnancy. Regarding neonatal aspects, the composite morbidity of period II was significantly decreased compared with that of period I, as assessed with a generalized estimating equation for logistic regression (26.2% vs. 8.1%, P=0.03). Multivariable analysis revealed that the gestational age at delivery and the period were significantly associated with the composite neonatal morbidity (P<0.001 and 0.007, respectively). CONCLUSION: Improved neonatal morbidity was associated with a higher gestational age at delivery and with the more recent decade.
