Is preeclampsia itself a risk factor for the development of metabolic syndrome after delivery?
10.5468/ogs.2019.62.4.233
- Author:
Geum Joon CHO
1
;
Un Suk JUNG
;
Jae Young SIM
;
Yoo Jin LEE
;
Na Young BAE
;
Hye Jin CHOI
;
Jong Heon PARK
;
Hai Joong KIM
;
Min Jeong OH
Author Information
1. Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Korea. mjohmd@korea.ac.kr
- Publication Type:Original Article
- Keywords:
Preeclampsia;
Metabolic syndrome;
Cardiovascular disease;
Diabetes mellitus;
Hypertension
- MeSH:
Blood Pressure;
Body Mass Index;
Cardiovascular Diseases;
Child;
Cholesterol;
Diabetes Mellitus;
Female;
Humans;
Hypertension;
Lipoproteins;
Mass Screening;
National Health Programs;
Postpartum Period;
Pre-Eclampsia;
Prevalence;
Risk Factors;
Triglycerides;
Waist Circumference
- From:Obstetrics & Gynecology Science
2019;62(4):233-241
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: This study aimed to determine the association between preeclampsia and the postpartum development of metabolic syndrome based on the pre-pregnancy status. METHODS: Korean women who delivered their first child between January 1, 2011, and December 31, 2012, were enrolled. All subjects underwent a national health screening examination conducted by the National Health Insurance Corporation 1 or 2 years prior to their first delivery and within 2 years after their first delivery. RESULTS: Among the 49,065 participants, preeclampsia developed in 3,391 participants (6.9%). The prevalence of metabolic syndrome was higher postpartum in women with preeclampsia than in those without preeclampsia (4.9% vs. 2.7%, respectively, P<0.001). Through the pre-pregnancy to postpartum period, women with preeclampsia had a greater increase in gestational weight retention, body mass index, waist circumference, systolic blood pressure, and triglyceride levels and a greater decrease in high-density lipoprotein cholesterol levels than women without preeclampsia. Preeclampsia was associated with an increased risk of the postpartum development of metabolic syndrome in women without pre-pregnancy metabolic syndrome (odds ratio, 1.28; 95% confidence interval, 1.05–1.56). However, preeclampsia was not associated with postpartum metabolic syndrome in women with pre-pregnancy metabolic syndrome or 2 components of metabolic syndrome. CONCLUSION: In this study, preeclampsia was associated with the postpartum development of metabolic syndrome in women without pre-pregnancy metabolic syndrome. However, the effects were attenuated by predisposing risk factors in the pre-pregnancy period.
