Albizzia julibrissin Suppresses Testosterone-induced Benign Prostatic Hyperplasia by Regulating 5α-Reductase Type 2 – Androgen Receptor Pathway
10.20307/nps.2019.25.3.200
- Author:
Geum Lan HONG
1
;
Hyun Tae KIM
;
Se Ra PARK
;
Na Hyun LEE
;
Kyung A RYU
;
Tae Won KIM
;
Gyu Yong SONG
;
Ju Young JUNG
Author Information
1. Department of Veterinary Medicine & Institute of Veterinary Science, Chungnam National University, Daejeon, Republic of Korea. jyjung@cnu.ac.kr
- Publication Type:Original Article
- Keywords:
Benign prostate hyperplasia;
Albizzia julibrissin;
5α-reductase type 2;
androgen receptor;
proliferating cell nuclear antigen
- MeSH:
Albizzia;
Animals;
Blood Circulation;
Blotting, Western;
Diethylpropion;
Epithelial Cells;
Herbal Medicine;
Humans;
Hyperplasia;
In Vitro Techniques;
Inflammation;
Lower Urinary Tract Symptoms;
Male;
Proliferating Cell Nuclear Antigen;
Prostate;
Prostate-Specific Antigen;
Prostatic Hyperplasia;
Rats;
Rats, Sprague-Dawley;
Receptors, Androgen;
Testosterone;
Weights and Measures
- From:Natural Product Sciences
2019;25(3):200-207
- CountryRepublic of Korea
- Language:English
-
Abstract:
Albizzia julibrissin (AJ) is an herbal medicine that shows low toxicity, promotes promoting blood circulation and mitigates the inflammation and has mild side effects. Benign prostate hyperplasia (BPH) is one of the most common diseases that occurs in older males and often results in lower urinary tract symptoms. This study was conducted to evaluate the protective effect of AJ against BPH using LNCaP cells and Sprague Dawley rats treated with testosterone. Treatment with AJ extract reduced the expression of androgen receptor (AR) and prostate-specific antigen (PSA) in vitro. In vivo, rats were divided into 6 groups: 1 (Normal Control); 2 (Testosterone propionate (TP) alone); 3 (TP + finasteride); 4 (TP + AJ 10 mg/kg); 5 (TP + AJ 50 mg/kg); 6 (TP + AJ 300 mg/kg). The groups treated with AJ showed reduced the relative prostate weights and BPH-related proteins were altered, with decreased AR, PSA and proliferating cell nuclear antigen (PCNA) observed by western blot. Histopathological analysis revealed the therapeutic effect of AJ, with a decreased thickness of epithelial cells and reduced level of PCNA and 5α-reductase type 2. These results suggest that AJ extract could ameliorate testosterone-induced benign prostatic hyperplasia.
