Xylaroisopimaranin A, a New Isopimarane Derivative from an Endophytic Fungus Xylaralyce sp.
10.20307/nps.2019.25.3.228
- Author:
Shang Song BAO
1
;
Hui Hui LIU
;
Xue Qing ZHANG
;
Cheng Xiong LIU
;
Xiao Cong LI
;
Zhi Yong GUO
Author Information
1. Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Science, China Three Gorges University, Yichang, Hubei Province 443002, People's Republic of China. zhyguoctgu@foxmail.com
- Publication Type:Original Article
- Keywords:
Endophytic fungus;
Xylaralyce sp.;
Structural elucidation;
Brine shrimp inhibition
- MeSH:
Artemia;
Fungi;
Griseofulvin;
Hep G2 Cells
- From:Natural Product Sciences
2019;25(3):228-232
- CountryRepublic of Korea
- Language:English
-
Abstract:
Five secondary metabolites, including a new isopimarane derivative xylaroisopimaranin A (1), were isolated from the endophytic fungus Xylaralyce sp. (HM-1), and their structures were elucidated by 1D, 2D NMR, MS and CD spectra. Their bioactivities were performed to antibacterial, Hep G2 cells cytotoxicity and brine shrimp inhibition. The biological evaluation results showed that the xylaroisopimaranin A (1), xylabisboein B (2), griseofulvin (3) , 5-methylmellein (4) and mellein-5-carboxlic acid (5) displayed no significant Hep G2 cells cytotoxicity and antibacterial acitivity, but they inhibited the brine shrimp with IC₅₀ from 0.5 to 25 µmol/mL.
