Diels-Alder Type Adducts from Hairy Root Cultures of Morus macroura
10.20307/nps.2019.25.3.233
- Author:
Nizar HAPPYANA
1
;
Euis H HAKIM
;
Yana M SYAH
;
Oliver KAYSER
;
Lia D JULIAWATY
;
Didin MUJAHIDIN
;
Tri M ERMAYANTI
;
Sjamsul A ACHMAD
Author Information
1. Chemistry Study Program, Faculty of Mathematics and Natural Sciences, Bandung Institute of Technology, Jl. Ganesha 10, 40132 Bandung, Indonesia. nizar@chem.itb.ac.id
- Publication Type:Original Article
- Keywords:
Diels-Alder type adduct;
Morus macroura;
tissue cultures;
cytotoxicity
- MeSH:
Cell Line;
Inhibitory Concentration 50;
Leukemia;
Methods;
Morus
- From:Natural Product Sciences
2019;25(3):233-237
- CountryRepublic of Korea
- Language:English
-
Abstract:
Three Diels-Alder type adducts, guangsangon E (1), chalcomoracin (2) and sorocein I (3) were isolated from hairy root cultures of Morus macroura. The structures of the isolated compounds (1 – 3) were determined by spectroscopic method (NMR and MS), and spectral comparison to literature. Cytotoxic activities of the isolated compounds (1 – 3) were investigated against P-388 murine leukemia cell line. Guangsangon E (1) showed the most potent cytotoxicity against P-388 murine leukemia cell line with IC₅₀ value of 2.75 ± 0.32 µg/mL. To the best of our knowledge, guangsangon E (1) and sorocein I (3) were reported for the first time from the tissue cultures of M. macroura.
