Flavestin K, An Isoprenylated Stilbene from the Leaves of Macaranga recurvata Gage
10.20307/nps.2019.25.3.244
- Author:
Tjitjik Srie TJAHJANDARIE
1
;
Mulyadi TANJUNG
;
Ratih Dewi SAPUTRI
;
Puja Bintu NADAR
;
Muhammad Fajar ALDIN
;
EVAMARLIANA
;
Anton PERMADI
Author Information
1. Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia. tjitjiktjahjandarie@fst.unair.ac.id
- Publication Type:Original Article
- Keywords:
Flavestin K;
Stilbene;
Macaranga recurvata;
Cytotoxicity
- MeSH:
Doxorubicin;
Euphorbiaceae;
Flavanones;
HeLa Cells;
Humans;
Stilbenes
- From:Natural Product Sciences
2019;25(3):244-247
- CountryRepublic of Korea
- Language:English
-
Abstract:
A new isoprenylated stilbene, flavestinK (1) together with two known isoprenylated stilbenes, flavestin B (2), flavestin G (3), and two isoprenilated flavanones, 4-O-methyl-8-isoprenylnaringenin (4) and 8-isoprenyl-5,7-dihydroxyflavanone (5) were isolated from the leaves of Macaranga recurvata Gage. All of the structures have been determined based on HRESIMS, 1D and 2D NMR spectral data. All of the isolated compounds were evaluated for their cytotoxicity against three human cancer cells (HeLa, T47D and WiDr). Compound 1 showed higher activity than doxorubicin against HeLa cells with IC₅₀ value of 13.1 µg/mL.
