Phytochemical Constituents of the Root Bark from Morus alba and Their Il-6 Inhibitory Activity
10.20307/nps.2019.25.3.268
- Author:
Young Su CHANG
1
;
Hong Guang JIN
;
Hwan LEE
;
Dong Sung LEE
;
Eun Rhan WOO
Author Information
1. College of Pharmacy, Chosun University, Gwangju 61452, Republic of Korea. wooer@chosun.ac.kr
- Publication Type:Original Article
- Keywords:
Morus alba L.;
Moraceae;
Prenylated flavonoid;
Il-6 inhibitory effect
- MeSH:
Asthma;
Chromatography;
Cough;
Edema;
Flavonoids;
Hematemesis;
Humans;
Hypertension;
Interleukin-6;
Moraceae;
Morus;
Plants, Medicinal
- From:Natural Product Sciences
2019;25(3):268-274
- CountryRepublic of Korea
- Language:English
-
Abstract:
Morus alba L., known as white mulberry, is a medicinal plant belongs to family Moraceae. It has long been used commonly in Ayurvedic for the treatment of lung-heat, cough, asthma, hematemesis, dropsy and hypertension. In the present study, seven prenylated flavonoids, along with four benzofuran compounds were isolated by means of repeated column chromatography. The structures of the known compounds were identified as kuwanon G (1), kuwanon E (2), kuwanon T (3), morusin (4), sanggenon A (5), sanggenon M (6), sanggenol A (7), moracin R (8), mulberofuran G (9), mulberofuran A (10) and mulberofuran B (11), by comparing their spectroscopic data with those reported in the literature. For these isolates, containing trace compounds, the inhibitory activity against IL-6 production in TNF-α stimulated MG-63 cells was examined. All isolated compounds (1
