Chemical Constituents from Solenostemma argel and their Cholinesterase Inhibitory Activity
10.20307/nps.2019.25.2.115
- Author:
Rym Gouta DEMMAK
1
,
2
;
Simon BORDAGE
;
Abederrahmane BENSEGUENI
;
Naima BOUTAGHANE
;
Thierry HENNEBELLE
;
El Hassen MOKRANI
;
Sevser SAHPAZ
Author Information
1. Laboratoire de Biochimie Appliquée, Département des Sciences de la Nature et de la Vie, Université Frères Mentouri-Constantine 1
2. 25000 Constantine, Algeria. rym.demmak@umc.edu.dz
- Publication Type:Original Article
- Keywords:
Alzheimer's disease;
Cholinesterase;
Molecular docking;
Solenostemma argel
- MeSH:
Acetylcholinesterase;
Alzheimer Disease;
Butyrylcholinesterase;
Cholinesterases;
Hydrogen;
In Vitro Techniques;
Neurodegenerative Diseases
- From:Natural Product Sciences
2019;25(2):115-121
- CountryRepublic of Korea
- Language:English
-
Abstract:
Alzheimer's disease is a chronic neurodegenerative disorder with no curative treatment. The commercially available drugs, which target acetylcholinesterase, are not satisfactory. The aim of this study was to investigate the cholinesterase inhibitory activity of Solenostemma argel aerial part. Eight compounds were isolated and identified by NMR: kaempferol-3-O-glucopyranoside (1), kaempferol (2), kaempferol-3-glucopyranosyl(1→6)rhamnopyranose (3) p-hydroxybenzoic acid (4), dehydrovomifoliol (5), 14,15-dihydroxypregn-4-ene-3,20-dione (6), 14,15-dihydroxy-pregn-4-ene-3,20-dione-15β-D-glucopyranoside (7) and solargin I (8). Two of them (compounds 2 and 3) could inhibit over 50 % of butyrylcholinesterase activity at 100 µM. Compound (2) displayed the highest inhibitory effect against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with a slight selectivity towards the latter. Molecular docking studies supported the in vitro results and revealed that (2) had made several hydrogen and π-π stacking interactions which could explain the compound potency to inhibit AChE and BChE.