Chemical Constituents of Impatiens balsamina Stems and Their Biological Activities
10.20307/nps.2019.25.2.130
- Author:
Dong Hyun KIM
1
;
Tae Hyun LEE
;
Lalita SUBEDI
;
Sun Yeou KIM
;
Kang Ro LEE
Author Information
1. Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea. krlee@skku.ac.kr
- Publication Type:Original Article
- Keywords:
Impatiens balsamina;
balsaminaceae;
tetrahydronaphthalene;
neuroprotective effect
- MeSH:
Balsaminaceae;
Chromatography;
Glioma;
Impatiens;
Inhibitory Concentration 50;
Nerve Growth Factor;
Neuroprotective Agents;
Statistics as Topic
- From:Natural Product Sciences
2019;25(2):130-135
- CountryRepublic of Korea
- Language:English
-
Abstract:
The purification of the MeOH extract from Impatiens balsamina by repeated column chromatography led to the isolation of one new tetrahydronaphthalene (1), together with eleven known compounds (2 – 12). The structure of the new compound (1) was determined by spectral data analysis (1H and 13C-NMR, 1H-1H COSY, HSQC, HMBC, NOESY, and HR-ESI-MS). Isolated compounds (1 – 12) were evaluated for their inhibitory effects on NO production in LPS-activated murine microglial BV-2 cells and their effects on NGF secretion from C6 glioma cells. Compounds 3, 7, and 10 reduced NO levels in LPS-activated murine microglial cells with IC50 values of 26.89, 25.59, and 44.21 µM, respectively. Compounds 1, 5, and 9 upregulated NGF secretion to 153.09 ± 4.66, 156.88 ± 8.86, and 157.34 ± 3.30%, respectively.
