Identification of a Novel Function of Extract of Gingko biloba (EGb 761®) as a Regulator of PYY Secretion and FFA4 Activation
10.20307/nps.2019.25.2.165
- Author:
Hye Young KIM
1
;
Kyong KIM
Author Information
1. Research Group of Natural Material and Metabolism, Division of Functional Food Research, Korea Food Research Institute, 245 Nongsaengmyeong-ro, Iseo-myeon, Wanju-gun, Jeollabuk-do 55365, Korea. khyey@kfri.re.kr
- Publication Type:Original Article
- Keywords:
EGb 761®;
Peptide tyrosine tyrosine;
Free fatty acid receptor 4;
NCI-H716 cells
- MeSH:
Brain;
Ginkgo biloba;
Homeostasis;
Neurons;
Tyrosine
- From:Natural Product Sciences
2019;25(2):165-171
- CountryRepublic of Korea
- Language:English
-
Abstract:
Although the functions of a standardized extract of Gingko biloba leaves (EGb 761®) has been reported with regard to neurobiological properties, no attention has been paid to the impact of EGb 761® on the neuronal regulation of energy homeostasis. To evaluate the hypothesis that EGb 761® affect the secretion of peptide tyrosine tyrosine (PYY) and the activation of free fatty acid receptor 4 (FFA4), which are involved in the neuronal circuitries that control energy homeostasis by inducing the transfer of information about the influx of energy to the brain, we examined whether EGb 761® can stimulate PYY secretion in the enteroendocrine NCI-H716 cells and if EGb 761® can activate FFA4 in FFA4-expressing cells. In NCI-H716 cells, EGb 761® stimulated PYY secretion and the EGb 761®-induced PYY secretion was involved in the increase in intracellular Ca2+ concentration and the activation of FFA4. Furthermore, in FFA4-expressing cells, EGb 761® activated FFA4. These results suggest that EGb 761® may affect the control of energy homeostasis via the regulation of PYY secretion and FFA4 activation.
