Acute Monoblastic Leukemia with t(11;17)(q23;q21): Fusion of the KMT2A(MLL) and MLLT6(AF17) Genes

Author: Cheon Gang PARK ¹ ; Seon Ho MUN ; A Jin LEE ; Chang Ho JEON ; Hun Suk SUH ; Sang Gyung KIM
Author Information

1. Department of Laboratory Medicine, Daegu Catholic University School of Medicine, Daegu, Korea. sgkim@cu.ac.kr
Publication Type:Case Report
Keywords: Acute monoblastic leukemia; AML; KMT2A; MLL; MLLT6
MeSH: Arm; Chromosomes, Human, Pair 17; Korea; Leukemia; Leukemia, Monocytic, Acute; Molecular Biology
From:Laboratory Medicine Online 2019;9(4):258-262
CountryRepublic of Korea
Language:English
Abstract: The KMT2A (formerly MLL) gene is associated with at least 10% of all cases of acute leukemia. More than 80 translocation partner genes of KMT2A have been discovered to date, six of which have been identified on the long arm of chromosome 17. Among these, the MLLT6 (formerly AF17) gene is located at 17q12 and fuses with the KMT2A gene in rare cases of acute leukemia. We report here a case of AML with a KMT2A/MLLT6 fusion that was confirmed using molecular genetic methods. According to a literature review, this is the first reported case of AML with a KMT2A/MLLT6 fusion in Korea.