Trends in Bloodstream Infections and Antimicrobial Susceptibilities at a University Hospital in Korea Between 2007 and 2016
- Author:
Sangeun LIM
1
;
Joon Sup YEOM
;
Eun Jeong JOO
;
Hae Suk CHEONG
;
Kyunghoon LEE
;
Hee Yeon WOO
;
Hyosoon PARK
;
Min Jung KWON
Author Information
- Publication Type:Original Article
- Keywords: Blood culture; Bacteremia; Identification; Antimicrobial susceptibility test
- MeSH: Bacteremia; Candida; Candida albicans; Drug Resistance; Enterococcus; Escherichia coli; Fungi; Gram-Positive Cocci; Klebsiella pneumoniae; Korea; Methicillin Resistance; Methicillin-Resistant Staphylococcus aureus; Methods; Pneumonia; Pseudomonas aeruginosa; Staphylococcus aureus; Staphylococcus epidermidis
- From:Laboratory Medicine Online 2019;9(2):63-72
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: Blood culture is an important method for identifying infectious microorganisms and confirming that a selected antimicrobial treatment is appropriate. In this study, we investigated the annual changes in the frequencies of blood isolates and antibiotic susceptibility test (AST) results. METHODS: We created a large database comprising data on all patient-unique blood cultures obtained from January 2007 through December 2016. Blood specimens were cultured using the BD BACTEC FX system, and species identification and AST were performed using the VITEK 2 system. RESULTS: During the 10-year study period, a total of 203,651 blood culture results were collected. Of these, gram-positive cocci, gram-negative rods, and fungi were isolated in 2.15%, 0.55%, and 0.12% of the blood cultures, respectively. Escherichia coli was the most commonly isolated species (22.8%), followed by Staphylococcus epidermidis (16.8%), Klebsiella pneumoniae (8.1%), and Staphylococcus aureus (8.0%). Fungal species were isolated in 3.0% of all positive blood cultures. Candida albicans was the most commonly isolated species (1.1%), followed by Candida parapsilosis (0.6%). Methicillin resistance was seen in 55.2% of S. aureus isolates. The frequencies of vancomycin-resistant Enterococcus (VRE) and carbapenem-resistant Pseudomonas aeruginosa (CRPA) were 13.1% and 10.9%, respectively. The isolation rates of MRSA, VRE, and CRPA showed different patterns each year. CONCLUSIONS: Among the isolates, E. coli was the most common, followed by S. epidermidis and K. pneumoniae. This study represents a long-term analysis of bloodstream infections, and the results can be used to identify trends in the microorganisms isolated and their drug resistance.
