Prevalence and molecular characteristics of 16s rRNA methylase gene rmtB in amikacin resistant Escherichia coli isolated from South Korea
10.14405/kjvr.2019.59.3.157
- Author:
Kuastros Mekonnen BELAYNEHE
1
;
Ho Geun WON
;
In Joong YOON
;
Han Sang YOO
Author Information
1. Department of Infectious Diseases, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea. yoohs@snu.ac.kr
- Publication Type:Brief Communication
- Keywords:
Escherichia coli;
16S RMTase gene;
amikacin resistance;
transferability
- MeSH:
Agriculture;
Amikacin;
Aminoglycosides;
Animals;
Escherichia coli;
Escherichia;
Gram-Negative Bacteria;
Humans;
Korea;
Prevalence;
Tissue Donors
- From:Korean Journal of Veterinary Research
2019;59(3):157-160
- CountryRepublic of Korea
- Language:English
-
Abstract:
The production of rmtB-encoded 16S rRNA methylases has emerged as a novel mechanism promoting high-level resistance toward aminoglycosides in Gram-negative bacteria. Between 2015 and 2017, 636 distinct commensal Escherichia (E.) coli isolates were collected from different farms in South Korea to determine the prevalence and molecular characteristics of rmtB. The positive rates of rmtB between all the isolates and amikacin-resistant isolates were 1.1 and 100%, respectively. High-level aminoglycoside resistance could be transferred by conjugation from rmtB-positive donors to higher amikacin-resistance efficacies. This is the first report of 16S rRNA methylase-encoding genes in E. coli isolated from food-producing animals in Korea.
