Structural and Functional Features on Quantitative Chest Computed Tomography in the Korean Asian versus the White American Healthy Non-Smokers
- Author:
Hyun Bin CHO
1
;
Kum Ju CHAE
;
Gong Yong JIN
;
Jiwoong CHOI
;
Ching Long LIN
;
Eric A HOFFMAN
;
Sally E WENZEL
;
Mario CASTRO
;
Sean B FAIN
;
Nizar N JARJOUR
;
Mark L SCHIEBLER
;
R Graham BARR
;
Nadia HANSEL
;
Christopher B COOPER
;
Eric C KLEERUP
;
MeiLan K HAN
;
Prescott G WOODRUFF
;
Richard E KANNER
;
Eugene R BLEECKER
;
Stephen P PETERS
;
Wendy C MOORE
;
Chang Hyun LEE
;
Sanghun CHOI
;
Author Information
- Publication Type:Original Article
- Keywords: Hydraulic luminal diameter; Airway wall thickness; Image registration; Percent emphysema-like lung; Percent functional small airway disease-like lung
- MeSH: Asian Continental Ancestry Group; Asthma; Continental Population Groups; Female; Forced Expiratory Volume; Humans; Lung; Lung Diseases; Phenotype; Prevalence; Pulmonary Disease, Chronic Obstructive; Thorax; Trachea; Vital Capacity
- From:Korean Journal of Radiology 2019;20(7):1236-1245
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVE: Considering the different prevalence rates of diseases such as asthma and chronic obstructive pulmonary disease in Asians relative to other races, Koreans may have unique airway structure and lung function. This study aimed to investigate unique features of airway structure and lung function based on quantitative computed tomography (QCT)-imaging metrics in the Korean Asian population (Koreans) as compared with the White American population (Whites). MATERIALS AND METHODS: QCT data of healthy non-smokers (223 Koreans vs. 70 Whites) were collected, including QCT structural variables of wall thickness (WT) and hydraulic diameter (Dh) and functional variables of air volume, total air volume change in the lung (ΔVair), percent emphysema-like lung (Emph%), and percent functional small airway disease-like lung (fSAD%). Mann-Whitney U tests were performed to compare the two groups. RESULTS: As compared with Whites, Koreans had smaller volume at inspiration, ΔVair between inspiration and expiration (p < 0.001), and Emph% at inspiration (p < 0.001). Especially, Korean females had a decrease of ΔVair in the lower lobes (p < 0.001), associated with fSAD% at the lower lobes (p < 0.05). In addition, Koreans had smaller Dh and WT of the trachea (both, p < 0.05), correlated with the forced expiratory volume in 1 second (R = 0.49, 0.39; all p < 0.001) and forced vital capacity (R = 0.55, 0.45; all p < 0.001). CONCLUSION: Koreans had unique features of airway structure and lung function as compared with Whites, and the difference was clearer in female individuals. Discriminating structural and functional features between Koreans and Whites enables exploration of inter-racial differences of pulmonary disease in terms of severity, distribution, and phenotype.
