Association between Thyroid-Related Hormones and Cognitive Function in Patients with Alzheimer's Disease and Mild Cognitive Impairment
10.22722/KJPM.2019.27.1.60
- Author:
Da Yun PARK
1
;
Hyun KIM
;
Kang Joon LEE
Author Information
1. Department of Psychiatry, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea. lkj@paik.ac.kr
- Publication Type:Original Article
- Keywords:
Thyroid hormones;
Alzheimer's disease;
Mild cognitive impairment
- MeSH:
Alzheimer Disease;
Cognition;
Dementia;
Depression;
Executive Function;
Humans;
Immunoassay;
Mild Cognitive Impairment;
Prospective Studies;
Retrospective Studies;
Thyroid Hormones;
Thyrotropin;
Thyroxine
- From:Korean Journal of Psychosomatic Medicine
2019;27(1):60-68
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: The association between thyroid-related hormones and cognitive function has been controversial. The purpose of this study is to compare the levels of thyroid-related hormones in patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI). Furthermore, we investigated the relationship between thyroid-related hormones and cognitive function. METHODS: From January 2011 to December 2018, we retrospectively reviewed 105 patients who were diagnosed with AD and MCI by visiting a dementia clinic at Ilsan Paik Hospital. Thyroid-related hormones [triiodothyronine (T3), thyroxine (T4), and thyroid stimulating hormone (TSH)] was measured using chemiluminescent immunoassay. An independent sample t-test was performed to analyze the mean value of thyroid-related hormones in patients of AD and MCI. To investigate whether thyroid-related hormones correlate significantly with Global deterioration scale (GDS), Clinical dementia rating (CDR) and scores of each The Korean version of the consortium to establish a registry for Alzheimer's disease items, we conducted a partial correlation analysis with geriatric depression scale-Korean version (GDS-K) scores as covariates. RESULTS: There was no significant difference in the mean serum T3, T4 and TSH levels between patients of the AD and the MCI, but the Construction Praxis Test (CPT) showed a significant positive correlation with the serum TSH concentration (p-value=0.004). CONCLUSIONS: In our study, the positive correlation between serum TSH level and the CPT associated with executive function was found to be helpful in understanding the association between thyroid-related hormones and the pathophysiology of dementia. Prospective studies in regard of the pathophysiology of thyroid-related hormones on cognitive function will be necessary in the future.
