Correlation of serum S100B levels with brain magnetic resonance imaging abnormalities in children with status epilepticus
- Author:
Prastiya Indra GUNAWAN
1
;
Darto SAHARSO
;
Dian Purnama SARI
Author Information
- Publication Type:Original Article
- Keywords: Status epilepticus; S100B; Magnetic resonance imaging; Child
- MeSH: Brain Diseases; Brain; Child; Diffusion Tensor Imaging; Head; Humans; Magnetic Resonance Imaging; Male; Observational Study; Seizures; Seizures, Febrile; Status Epilepticus
- From:Korean Journal of Pediatrics 2019;62(7):281-285
- CountryRepublic of Korea
- Language:English
- Abstract: PURPOSE: To evaluate the association between elevated S100B levels with brain tissue damage seen in abnormalities of head magnetic resonance imaging (MRI; diffusion tensor imaging [DTI] sequence) in patients with status epilepticus (SE). METHODS: An analytical observational study was conducted in children hospitalized at Dr Soetomo Hospital, Surabaya, from July to December 2016. The patients were divided into 2 groups: SE included all children with a history of SE; control included all children with febrile seizure. Blood samples of patients were drawn within 24 hours after admission. SE patients also underwent cranial MRI with additional DTI sequencing. The Mann-Whitney test and Spearman test were used for statistical analysis. RESULTS: Fifty-three patients were enrolled the study. In the 24 children with SE who met the inclusion criteria, serum S100B and cranial MRI findings were assessed. Twenty-two children admitted with febrile seizures became the control group. Most patients were male (66.7%); the mean age was 35.8 months (standard deviation, 31.09). Mean S100B values of the SE group (3.430±0.141 μg/L) and the control group (2.998±0.572 μg/L) were significantly different (P<0.05). A significant difference was noted among each level of encephalopathy based on the cranial MRI results with serum S100B levels and the correlation was strongly positive with a coefficient value of 0.758 (P<0.001). CONCLUSION: In SE patients, there is an increase of serum S100B levels within 24 hours after seizure, which has a strong positive correlation with brain damage seen in head MRI and DTI.
