The maternal prepregnancy body mass index and the risk of attention deficit hyperactivity disorder among children and adolescents: a systematic review and meta-analysis
- Author:
Ensiyeh JENABI
1
;
Saied BASHIRIAN
;
Salman KHAZAEI
;
Zohreh BASIRI
Author Information
- Publication Type:Meta-Analysis
- Keywords: Attention deficit disorder with hyperactivity; Body mass index; Pregnancy
- MeSH: Adolescent; Attention Deficit Disorder with Hyperactivity; Body Mass Index; Child; Epidemiologic Studies; Female; Humans; Obesity; Odds Ratio; Overweight; Pregnancy; Public Health; Risk Factors; Weight Gain
- From:Korean Journal of Pediatrics 2019;62(10):374-379
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: Attention deficit hyperactivity disorder (ADHD) symptoms have a major impact on individuals, families, and society. Therefore identification risk factors of ADHD are a public health priority. PURPOSE: This is meta-analysis evaluated the association between maternal prepregnancy body mass index and the risk of ADHD among the resulting offspring. METHODS: The search identified studies published through December 2018 in the PubMed, Web of Science, and Scopus databases. The odds ratios (ORs) or hazard ratios (HRs) with 95% confidence intervals (CI) extracted from eligible studies were used as the common measure of association among studies. RESULTS: A significant association was found between overweight women and the risk of ADHD among children with the pooled HR and OR estimates (HR, 1.27 and 95% CI, 1.17–1.37; OR, 1.28 and 95% CI, 1.15–1.40, respectively). This association was significant between obese women and the risk of ADHD among children and adolescents with the pooled estimates of HR and OR (HR, 1.65 and 95% CI, 1.55–1.76; OR, 1.42 and 95% CI, 1.23–1.61). CONCLUSION: The current epidemiological studies present sufficient evidence that prepregnancy overweight and obesity are significantly associated with an increased risk of ADHD among children and adolescents. These findings provide a new approach to preventing ADHD by controlling weight gain in the prenatal period, which should be considered by policymakers.
