Complete Remission of Metastatic Duodenal Neuroendocrine Carcinoma Treated with Chemotherapy and Surgical Resection
10.15279/kpba.2019.24.3.121
- Author:
Jong Hwa WON
1
;
Ji Kon RYU
Author Information
1. Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea. jkryu@snu.ac.kr
- Publication Type:Case Report
- Keywords:
Neuroendocrine tumors;
Neoplasm metastasis;
Induction chemotherapys
- MeSH:
Carcinoma, Neuroendocrine;
Cisplatin;
Diagnosis;
Drug Therapy;
Etoposide;
Humans;
Liver;
Male;
Middle Aged;
Neoplasm Metastasis;
Neuroendocrine Tumors;
Pancreaticoduodenectomy;
Positron-Emission Tomography
- From:Korean Journal of Pancreas and Biliary Tract
2019;24(3):121-126
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
A 57-year-old male with periampullary duodenal mass was diagnosed as grade 3 duodenal neuroendocrine carcinoma with multiple liver metastasis. After nine cycles of cisplatin and etoposide, abdominal computed tomography (CT) findings showed complete regression of primary duodenal mass with marked size reduction of liver metastasis. Positron emission tomography findings showed metabolic complete response in both duodenal and liver mass. Pylorus-preserving pancreaticoduodenectomy was done and pathologic finding showed 5 mm sized remnant neuroendocrine tumor. The patient has remained alive with no evidence of disease for 43 months after initial diagnosis. This case suggests the possibility of heterogeneous nature of grade 3 neuroendocrine carcinoma and selected population may have extreme sensitivity to cisplatin and etoposide chemotherapy leading to complete response.
