Diagnostic Performance of Diffusion-weighted Imaging for Hepatic Neuroendocrine Tumor: Comparison with Combined Diffusion-weighted Imaging and Contrast-enhanced Magnetic Resonance Imaging.
10.17998/jlc.2016.16.2.92
- Author:
Suk Ki JANG
1
;
Jung Hoon KIM
;
Mi Hye YU
;
Joon Koo HAN
Author Information
1. Department of Radiology, Bundang Jesaeng Hospital, Seongnam, Korea.
- Publication Type:Original Article
- Keywords:
Diffusion-weighted imaging;
Hepatic neuroendocrine tumor;
Contrast-enhanced MRI;
Comparison study
- MeSH:
Humans;
Magnetic Resonance Imaging*;
Neuroendocrine Tumors*;
Sensitivity and Specificity
- From:Journal of Liver Cancer
2016;16(2):92-100
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: To investigate the diagnostic performance of diffusion-weighted imaging (DWI) for hepatic neuroendocrine tumors (NET) compared with combined DWI and contrast-enhanced magnetic resonance imaging (MRI). METHODS: Fifteen patients with hepatic NET (n=128) underwent enhanced MRI and DWI with multiple-b values. We analyzed three different sets: Precontrast set; DWI set (added DWI); combined set (added enhanced image). Two reviewers rated possibility of NET using a 5-point scale for each image set. Their diagnostic performance was compared using Jackknife alternative free-response ROC (JAFROC). RESULTS: Diagnostic performance was better on the combined set (figure of merit [FOM]=0.852, 0.761) than the precontrast set (FOM=0.427, 0.572, P〈0.05) and the DWI set (FOM=0.682, 0.620, P〈0.05). However, DWI improved performance compared with precontrast set without statistical difference. In small NETs (〈1 cm), all sets showed low sensitivity (10.7-65.9%) with high specificity (95.4-100%). Interobserver agreement was moderate in all image sets (k=0.521 to 0.589). CONCLUSIONS: Combined DWI and enhanced MRI were more useful for detecting NET. Although statistically insignficant, there was a trend in improved diagnostic performance with DWI.
