Location of Retinal Nerve Fiber Layer Defects in Open-angle Glaucoma and Associated Factors
- Author:
Han Ul KIM
1
;
Kyeong Ik NA
Author Information
- Publication Type:Original Article
- Keywords: Hypertension; Korea National Health and Nutrition Examination Survey; Open-angle glaucoma; Retinal nerve fiber layer defect
- MeSH: Glaucoma, Open-Angle; Hypertension; Korea; Multivariate Analysis; Nerve Fibers; Nutrition Surveys; Ophthalmology; Retinaldehyde; Retrospective Studies
- From:Korean Journal of Ophthalmology 2019;33(4):379-385
- CountryRepublic of Korea
- Language:English
- Abstract: PURPOSE: To investigate the location of retinal nerve fiber layer defects (RNFLDs) in open-angle glaucoma and the differences in systemic and ocular factors between superotemporal and inferotemporal RNFLDs. METHODS: We performed a retrospective review of the 2008 to 2012 data from the Korea National Health and Nutrition Examination Survey. Subjects aged ≥19 years with an evaluable fundus photograph of at least one eye were enrolled, and open-angle glaucoma was diagnosed according to modified International Society of Geographical and Epidemiological Ophthalmology criteria. In subjects with open-angle glaucoma, locations of RNFLDs were evaluated, and systemic and ocular factors were compared between the bilateral superotemporal RNFLD group and bilateral inferotemporal RNFLD group. RESULTS: A total of 534 subjects had open-angle glaucoma with RNFLDs. The unilateral inferotemporal region (25.8%) was the most common location for RNFLDs, followed by the unilateral superotemporal region (24.4%). Multivariate analysis revealed that hypertension was more significantly associated (p = 0.048) with the bilateral superotemporal RNFLD group than with the bilateral inferotemporal RNFLD group. CONCLUSIONS: Superotemporal RNFLDs are more related to hypertension than are inferotemporal RNFLDs.
